What is the use of benzimidazole?
The benzimidazole and its derivatives play a very important role as a therapeutic agent e.g. antiulcer and anthelmintic drugs. Apart from this the benzimidazole derivatives exhibit pharmacological activities such as antimicrobial, antiviral, anticancer, anti-inflammatory, analgesic, etc.
What is the mechanism of action of benzimidazoles?
Mechanism of action: Benzimidazoles interrupt parasite energy metabolism by binding to tubulin, thereby disrupting microtubular cell structure and preventing nutrient uptake and other functions.
How do you make benzimidazole?
Preparation. Benzimidazole is produced by condensation of o-phenylenediamine with formic acid, or the equivalent trimethyl orthoformate: C6H4(NH2)2 + HC(OCH3)3 → C6H4N(NH)CH + 3 CH3OH. 2-substituted derivatives are obtained when the condensation is conducted with aldehydes in place of formic acid, followed by oxidation …
What is the molecular formula of benzimidazole?
C7H6N2Benzimidazole / Formula
What is substituted benzimidazole?
The novel antiulcer drugs omeprazole, lansoprazole, and pantoprazole are members of the class of substituted benzimidazoles.
Which is commonly used benzimidazole derivatives as anthelmintic?
Fenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms,…
What is the molecular weight of benzimidazole?
118.14 g/molBenzimidazole / Molar mass
What are imidazole derivatives?
Many imidazole-based derivatives have been marketed as antifungal drugs such as ketoconazole (1), miconazole (2), clotrimazole (3), tioconazole (4), econazole (5), tinidazole (6), enilconazole/imazalil (7), parconazole (8), eberconazole (9), lanoconazole (10), fenticonazole (11), bifonazole (12), sulconazole (13).
What is the generic name of mebendazole?
VERMOX™ (mebendazole) is an orally administered, synthetic anthelmintic available as chewable tablets, each containing 100 mg of mebendazole.