What is Kupffer cell hyperplasia?
Kupffer cell hypertrophy and hyperplasia usually occur together and can be seen following uptake of foreign material, test agent, or metabolite, any of which may impart a pigment to the cytoplasm. Kupffer hyperplasia and hypertrophy may also occur in inflammatory conditions.
What is the main function of Kupffer cells?
Although their main function is phagocytosis and defence of the liver against bacteria, endotoxaemia and viral infections, they also fulfil other important roles. They will phagocytose and partially degrade bacterial antigens before handing them on to the hepatocytes for excretion into the bile.
What is Kupffer cell of liver?
Kupffer cells are resident liver macrophages and play a critical role in maintaining liver functions. Under physiological conditions, they are the first innate immune cells and protect the liver from bacterial infections.
Where are Kupffer cells?
Kupffer cells (also known as stellate sinusoidal macrophages or Kupffer-Browicz cells) are macrophages found in the sinusoids of the liver. In fact, Kupffer cells make up 80% to 90% of all the macrophages in the entire human body.
Do Kupffer cells produce bile?
Kupffer cells, also known as stellate macrophages and Kupffer–Browicz cells, are specialized cells localized in the liver within the lumen of the liver sinusoids and are adhesive to their endothelial cells which make up the blood vessel walls….
|Anatomical terms of microanatomy|
Are Kupffer cells myeloid?
Myeloid populations present within the liver. Kupffer cells are derived from the yolk sac or hematopoietic stem cells, under the control of transcription factors such as ID3 and ZEB2.
What are von Kupffer cells?
Supplement. Kupffer cells are the specialized macrophages located in the liver, particularly at the lining of liver sinusoids. They are part of the mononuclear phagocyte system. Their name is derived from Karl Wilhelm von Kupffer, a German anatomist who was the first to describe them in 1876. 1.
What is the significance of Kupffer cell & stellate cell in liver cirrhosis?
Alcohol-related liver disease is a chronic inflammatory disease of the liver parenchyma due to chronic ethanol ingestion with the end result being alcoholic fibrosis and cirrhosis. Kupffer cells have been suggested to participate in this process mainly through the increased production of inflammatory mediators.
Who discovered Kupffer cells?
Karl Wilhelm von Kupffer
First described by Karl Wilhelm von Kupffer in 1876 as “sternzellen” (star cells or stellate cells), Kupffer cells were first thought to be a part of the endothelium of the liver blood vessels. It was not until 1898 that Tadeusz Browiecz correctly identified them as macrophages (92).
How are Kupffer cells best described?
The sinusoids are lined with phagocytic cells, known as Kupffer cells, which are part of the mononuclear phagocyte system and are the largest population of tissue macrophages in the body. They are bactericidal and central to innate immunity. None of the other options accurately describe Kupffer cells.
What causes hyperplasia?
Endometrial hyperplasia is caused by too much estrogen or not enough progesterone. Both of these hormones play roles in the menstrual cycle. Estrogen makes the cells grow, while progesterone signals the shedding of the cells. A hormonal imbalance can produce too many cells or abnormal cells.
What is the pathophysiology of Kupffer hyperplasia and hypertrophy?
Kupffer cell hypertrophy and hyperplasia usually occur together and can be seen following uptake of foreign material, test agent, or metabolite, any of which may impart a pigment to the cytoplasm. Kupffer hyperplasia and hypertrophy may also occur in inflammatory conditions. The enlarged Kupffer cells may form sheets or small nodules.
Does Kupffer cell hyperplasia occur in mice?
Kupffer cell hyperplasia and hypertrophy is rarely seen in mice. Hypertrophic Kupffer cells may contain pigment in some cases. Examples of Kupffer cell hyperplasia.
What is the meaning of Kupffer cells?
Kupffer cells – phagocytic cells of the mononuclear phagocyte series found on the luminal surface of the hepatic sinusoids. Synonym (s): stellate cells of liver
Do hypertrophic Kupffer cells contain pigment?
Hypertrophic Kupffer cells may contain pigment in some cases. Examples of Kupffer cell hyperplasia.