What is ecgonine methyl ester used for?
Ecgonine methyl ester is the O-debenzoyl analogue of cocaine. It has a role as a central nervous system depressant, a peripheral nervous system drug, an analgesic, a metabolite, an opioid analgesic and a mouse metabolite.
Is ecgonine methyl ester an active metabolite?
Pharmacogenomics of abused drugs Once absorbed, cocaine is rapidly metabolized into inactive metabolite ecgonine methyl ester by serum butylcholinesterase. Cocaine is also spontaneously hydrolyzed into benzoylecgonine, also an inactive metabolite.
What is Ecgonidine methyl ester?
Methylecgonidine (anhydromethylecgonine; anhydroecgonine methyl ester; AEME) is a chemical intermediate derived from ecgonine or cocaine.
What is the half life of ecgonine methyl ester?
Ecgonine methyl ester had an elimination halflife of 4.2 hr, compared with 5.1 hr for benzoylecgonine. These results indicate that ecgonine methyl ester accounts for most of the previously unidentified urinary metabolic products of cocaine.
What is EME drug?
EME (2,5-diethoxy-4-methoxyamphetamine) is a lesser-known psychedelic drug. It is a diethoxy-methoxy analog of TMA-2. EME was first synthesized by Alexander Shulgin. In his book PiHKAL, both the dosage and duration are unknown. EME produces few to no effects.
What is Norcocaine used for?
The local anesthetic potential of norcocaine has been shown to be higher than that of cocaine, however cocaine continues to be more widely used. Norcocaine used for research purposes is typically synthesized from cocaine….Norcocaine.
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Is procaine the same as novocaine?
procaine hydrochloride, also called Novocain, or Novocaine, synthetic organic compound used in medicine as a local anesthetic. Introduced in 1905 under the trade name Novocaine, it became the first and best-known substitute for cocaine in local anesthesia.
Where did coca plant originated?
Coca is an indigenous plant of South America with numerous alkaloid components, the most well-known one of which is the psychoactive component, cocaine. Its leaves have been a staple in the Andean lifestyle for thousands of years. Strong interest in coca use has existed in the anthropological world for decades.