What is a first line treatment definition?
The first treatment given for a disease. It is often part of a standard set of treatments, such as surgery followed by chemotherapy and radiation. When used by itself, first-line therapy is the one accepted as the best treatment.
What is first line and second line treatment?
Second-line treatment is treatment for a disease or condition after the initial treatment (first-line treatment) has failed, stopped working, or has side effects that aren’t tolerated. It’s important to understand “lines of treatment” and how they differ from first line treatment and can play a role in clinical trials.
What is a first line indication?
As the evidence and consensus for use of the drug increases and strengthens, its class of indication is improved. Preferred drugs (and other treatments) are also referred to a “first line” or “primary” while others are called “second line”, “third line” etc.
What is a second line drug?
Second line drugs are the TB drugs that are used for the treatment of drug resistant TB. The second line drugs include levofloxacin, moxifloxacin, bedaquiline, delamanid and linezolid. There is also pretomanid which is a new second line drug recommended in 2019 for the treatment of drug resistant TB.
What is a first-line antibiotic?
Amoxicillin or amoxicillin/clavulanate is the recommended first-line therapy. Macrolides such as azithromycin are not recommended due to high levels of Streptococcus pneumoniae antibiotic resistance (~40%).
What is the first-line treatment for Covid 19?
The FDA has approved the antiviral drug Veklury (remdesivir) for adults and certain pediatric patients with COVID-19. During public health emergencies, the FDA may authorize the use of unapproved drugs or unapproved uses of approved drugs under certain conditions. This is called an Emergency Use Authorization (EUA) .
What is the difference between adjuvant and first-line therapy?
Adjuvant therapy is any type of therapy that follows the primary treatment. So, adjuvant chemotherapy takes place after you’ve had first-line treatment, such as surgery to remove a cancerous tumor.
Which is the first-line Antitubercular drug?
Isoniazid (INH), rifampin (RIF), streptomycin (SM), and ethambotol (EMB) are first-line chemotherapeutic drugs used in TB therapy (Mohammadi et al., 2002).
What is first-line treatment for hypertension?
The strongest body of evidence indicates that for most patients with hypertension, thiazide diuretics are the best proven first-line treatment in reducing morbidity and mortality.
What would the first-line of treatment be for inflammation?
Nonsteroidal anti-inflammatory drugs (NSAIDs): NSAIDs are usually the first-line treatment for short-term pain and inflammation. Most of these medications are available over-the-counter, including aspirin, ibuprofen, and naproxen.
How does FDA define indication?
D. Medical Editor: Jay Marks, M.D. In medical terminology, an “indication” for a drug refers to the use of that drug for treating a particular disease. The Food and Drug Administration (FDA) classifies indications for drugs in the United States.
What is a third line drug?
Third line therapy is usually defined as a regimen for an individual who has developed resistance to at least one drug in all three classes of anti-HIV therapies [nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors] or has failed …