What triggers atypical HUS?

What triggers atypical HUS?

The cause of Stx HUS most frequently is infection by a particular strain (0157:H7) of Escherichia coli (E. coli) bacterium. Occasionally, adults may be affected by Stx HUS. (For more information on this disorder, choose “Typical Hemolytic Uremic Syndrome” as your search term in the Rare Disease Database.)

What is atypical hemolytic uremic syndrome?

Atypical hemolytic-uremic syndrome is a disease that primarily affects kidney function. This condition, which can occur at any age, causes abnormal blood clots (thrombi) to form in small blood vessels in the kidneys. These clots can cause serious medical problems if they restrict or block blood flow.

How is atypical HUS diagnosed?

The presence of a classic epidemic of bloody diarrhea or a confirmed positive Shiga toxin test will lead to the diagnosis of STEC-HUS.

How is aHUS treated?

Supportive treatment of aHUS: Treatment includes blood transfusions, dialysis if indicated, and blood pressure control. Patients on dialysis may develop malignant hypertension, and bilateral nephrectomy may be needed to achieve blood pressure control in some of these patients.

Is HUS an autoimmune disease?

The presence of mutations is what distinguishes aHUS from typical HUS — which is caused by a bacterial infection — and secondary HUS, which develops as a consequence of autoimmune diseases or organ transplants.

What is the difference between HUS and aHUS?

The classic form (typical HUS) is associated with a Shiga-like toxin often related to E. coli serotype O157:H7. The atypical HUS (aHUS) form is due to an overactivation of the alternative pathway of complement and carries a reserved prognosis with high mortality and morbidity in the acute phase.

Can you survive aHUS?

Atypical hemolytic uremic syndrome (aHUS) is a disease that causes blood clots in small blood vessels in your kidneys and other organs. These clots keep blood from getting to your kidneys, which can lead to serious medical problems, including kidney failure. There’s no cure, but treatment can help manage the condition.

What is iron deficiency anemia?

Iron deficiency anemia is a common type of anemia — a condition in which blood lacks adequate healthy red blood cells. Red blood cells carry oxygen to the body’s tissues. As the name implies, iron deficiency anemia is due to insufficient iron.

Can iron deficiency anemia cause shortness of breath?

As a result, iron deficiency anemia may leave you tired and short of breath. You can usually correct iron deficiency anemia with iron supplementation. Sometimes additional tests or treatments for iron deficiency anemia are necessary, especially if your doctor suspects that you’re bleeding internally.

What is the global prevalence of iron deficiency without anemia?

The global prevalence of anemia in pregnancy is estimated to be approximately 41.8%4; nevertheless, the percentage of iron deficiency without anemia is unknown. The overall iron requirement during pregnancy is significantly higher than in the non-pregnant state, despite the temporary respite from iron losses incurred during menstruation.

What are the long-term effects of iron deficiency anemia in infancy?

Algarin C, Peirano P, Garrido M, Pizzaro F, Lozoff B. Iron deficiency anemia in infancy: long-lasting effects on auditory and visual system functioning. Pediatr Res2003; 53:217–23. [PubMed] [Google Scholar] 62.