What is Mart melanoma?
MART-1 (melanoma antigen recognized by T cells 1) is a “widely shared melanoma antigen recognized by the T lymphocytes of patients with established malignancy.” MART-1 is one of the oldest identified tumor antigens and is a protein found on normal melanocytes in the skin and retina.
What is a mart-1 stain?
Melanoma antigen recognized by T cells or Melan-A (MART-1), is a protein with unknown function that is associated with endoplasmic reticulum and melanosomes. Melan A is a sensitive and specific marker for the diagnosis of melanoma.
What does a positive Mart-1 mean?
Conclusions: The MART-1 antibody is a superior immunohistochemical marker for the diagnosis of MM. It has the potential to become the preferred antibody over HMB-45 for the diagnosis of metastatic MM in FNA material, as MART-1 stains a higher percentage of lesions in a higher percentage of patients than does HMB-45.
Is melanoma S100 negative?
S100 negative melanomas are rare. S100P is positive in all subtypes of melanoma, including desmoplastic melanoma, for the diagnosis of which it remains an important reagent. Along with Sox10 and nerve growth factor receptor (NGFR), it is the most sensitive marker to visualize invasive melanoma (Fig.
Is Mart 1 the same as Melan A?
Melan-A, also known as MART-1, is an additional melanocytic marker and has proved to be useful in identifying metastatic tumors of melanocytic origin.
What does NY ESO 1 mean?
The CTA New York Esophageal Squamous Cell Carcinoma-1 (NY-ESO-1) is also known as cancer-testis antigen 1B (CTAG1B) and is encoded by the gene CTGAG1B which is located on the Xq28 region of the X chromosome.
What does positive Melan-A mean?
The presence of Melan-A positive dermal cells in excisions for melanoma in situ represents a frequent conundrum for pathologists. These cells may represent superficially invasive melanoma, benign, incidental, dermal nevi or non-specific staining of dermal melanophages.
What does HMB 45 stain?
HMB-45 is a widely used immunohistochemical stain for detection of primary as well as metastatic melanoma (1). Presumably, this method uses monoclonal antibodies to a glycoprotein that is present in premelanosomes (11).
What is Melan-A used for?
Melan-A, also known as MART-1, is an additional melanocytic marker and has proved to be useful in identifying metastatic tumors of melanocytic origin. The usefulness of this marker to discriminate pigmented actinic keratosis from early melanoma in situ, however, has not yet been a subject of investigation.
Is a compound melanocytic nevus malignant?
In adulthood, they are more likely to appear on the palms, soles, and the genital region. Compound nevi that appear in late adulthood are at increased risk for being malignant.