Is GLI1 an oncogene?

Is GLI1 an oncogene?

Human Gli1 encodes a transcription activator involved in development that is a known oncogene.

What does GLI3 gene do?

It plays a role in cell growth, cell specialization, and the patterning of structures such as the brain and limbs. Depending on signals from Sonic Hedgehog, the GLI3 protein can either turn on (activate) or turn off (repress) other genes.

What is GLI1 gene?

GLI1 (GLI Family Zinc Finger 1) is a Protein Coding gene. Diseases associated with GLI1 include Polydactyly, Postaxial, Type A8 and Polydactyly, Preaxial I. Among its related pathways are Signaling by Hedgehog and Activation of cAMP-Dependent PKA.

What does GLI1 stand for?


aa = Amino acid
GLI1 = Glioma-associated oncogene homologue 1
GSTP1 = Glutathione S-transferase P1
HNF-3β = Hepatocyte nuclear factor-3β
IGF-II = Insulin-like growth factor-II

What is Sonic Hedgehog pathway?

Sonic Hedgehog (Shh) signalling pathway is one of the major trafficking networks that regulates the key events during developmental processes i.e growth and patterning of multicellular embryos.

What is SMO mutation?

Smoothened (Smo) is a key transmembrane protein that is a key component of the hedgehog signaling pathway, a cell-cell communication system critical for embryonic development and adult tissue homeostasis. Mutations in proteins that relay Hh signals between cells cause birth defects and cancer.

Where is GLI3 located?

The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH1) gene expression. It is also thought to play a role during embryogenesis.

What is GLI Hedgehog pathway?

The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical role in controlling cell specification, cell–cell interaction and tissue patterning during embryonic development.

What is hedgehog mutation?

SHH gene mutations are the most common cause of nonsyndromic holoprosencephaly. These mutations reduce or eliminate the activity of Sonic Hedgehog. Without the correct activity of this protein, the eyes will not form normally and the brain does not separate into two hemispheres.

What does Sonic Hedgehog bind to?

The activation of Shh signal requires binding of Shh to the Ptc mediated Smoothened (Smo) (Ptc-smo) receptor complex and induction of downstream signalling cascade. This is a heterodimeric receptor complex. Ptc-Smo heterodimeric receptor complex consists of two trans-membrane subunits, namely Ptc and Smo.

What is Gli protein?

Gli proteins are members of the family of Kruppel-like factors with highly conserved Zn finger DNA-binding domains. In mammals, they are represented by three proteins: Gli1, Gli2 and Gli3.

What is SMO biology?