How is pulmonary toxicity diagnosed?

How is pulmonary toxicity diagnosed?

Imaging Tests

  1. Many people with PF actually have normal chest X-rays in the early stages of the disease.
  2. A high-resolution computed tomography scan, or HRCT scan, is an X-ray that provides sharper and more detailed pictures than a standard chest X-ray and is an important component of diagnosing PF.

How is drug-induced pulmonary toxicity treated?

The treatment of drug-induced lung disease consists of immediately discontinuing the offending drug and appropriately managing the pulmonary symptoms. Acute episodes of drug-induced pulmonary disease usually disappear 24-48 hours after the drug has been discontinued, but chronic syndromes may take longer to resolve.

What drugs cause interstitial lung disease?

Any chemotherapeutic drug can adversely affect the lung, but the drugs most commonly implicated in lung toxicity are bleomycin, carmustine, busulfan, and cyclophosphamide [43-46]. Approximately 1-10% of patients taking one of these drugs are affected. Bleomycin is the drug most commonly studied as a cause of DILD.

How is bleomycin toxicity treated?

Although there is no approved standard treatment for Bleomycin induced pulmonary toxicity, some of the most common approaches until date include witholding bleomycin from subsequent chemotherapy, continuing with a non-bleomycin based regimen in relevant patients or corticosteroid treatment.

Does cisplatin cause lung problems?

Renal damage, following cisplatin administration, with subsequent accumulation of bleomycin was the likely cause of the high lung toxicity. Extreme caution is recommended in the administration of combined bleomycin-cisplatin chemotherapy.

How is pulmonary fibrosis diagnosed?

Imaging tests

  1. Chest X-ray. A chest X-ray shows images of your chest.
  2. Computerized tomography (CT) scan. CT scanners use a computer to combine X-ray images taken from many different angles to produce cross-sectional images of internal structures in the body.
  3. Echocardiogram.

Can pulmonary toxicity be cured?

No cure exists. Medications may slow down scarring and help preserve lung function. Oxygen therapy and staying active may relieve symptoms.

Which drugs cause pulmonary toxicity?

Bleomycin, gold salts, cyclophosphamide, and methotrexate are the most common drugs that cause this form of lung injury (,2,,4,,11). Amiodarone, nitrofurantoin, penicillamine, and sulfasalazine are less common causes of drug-induced BOOP (,11).