How do you classify dyslipidemia?
The most common dyslipidemias are types IIA, IIB, and IV. Type I and type III hyperlipoproteinemia (HLP) are extremely rare in pediatric patients, and type V is uncommon.
What is Frederickson classification?
Hyperlipidemia has been defined by the Fredrickson classification, which is based on beta-quantification, a process involving ultracentrifugation followed by electrophoresis. In this system, shown in Table 1, below, all categories except type IIa are forms of hypertriglyceridemia.
What drug classes are used for dyslipidemia?
The most commonly used options for the pharmacologic treatment of dyslipidemia are statins, resins, fibrate, niacin, and their combinations.
What is difference between dyslipidemia and hyperlipidemia?
Hyperlipidemia refers to high levels of LDL or triglycerides. Dyslipidemia can refer to levels that are either higher or lower than the normal range for those blood fats.
What is Fredrickson Type IIa Hyperlipoproteinemia?
Familial hypercholesterolemia (FH) has an HLP2A (Frederickson type IIa) lipid profile. It is caused by mutations in multiple genes, most often the LDL receptor. One in 500 persons carry a mutation in this gene, and these heterozygotes present with planar, tendon, or tuberous xanthomas from age 30–60.
What are the classification of Hyperlipoproteinemia based on Fredrickson?
WHO/Fredrickson classification of primary hyperlipidaemias
| Type | Average of overnight serum | Elevated particles |
|---|---|---|
| IIb | Clear | LDL, VLDL |
| III | Turbid | IDL |
| IV | Turbid | VLDL |
| V | Creamy top, turbid bottom | Chylomicrons, VLDL |
What is the difference between Hyperlipoproteinemia and hyperlipidemia?
Hyperlipidemia is also called hyperlipoproteinemia and can be primary or secondary in origin. Various primary hyperlipidemias include: Familial hypercholesterolemia: This disease is transmitted as an autosomal dominant disorder.
What is Hyperlipoproteinemia type II?
A group of familial disorders characterized by elevated circulating cholesterol contained in either LOW-DENSITY LIPOPROTEINS alone or also in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins).
What is atherosclerosis Slideshare?
TERMS • Arteriosclerosis is a general term describing any hardening (and loss of elasticity) of medium or large arteries • Arteriolosclerosis is any hardening (and loss of elasticity) of arterioles (small arteries); • Atherosclerosis is a hardening of an artery specifically due to an atheromatous plaque.