How do endocrine disruptors cause obesity?

How do endocrine disruptors cause obesity?

Endocrine disrupting chemicals (EDCs) Exposure to EDCs during early years of development have been shown to increase the risk of developing various chronic diseases including obesity and diabetes [14]. EDCs cause weight gain by altering lipid metabolism to promote adipogenesis and lipid accumulation [15].

What are environmental endocrine disruptors?

Endocrine disruptors are natural or human-made chemicals that may mimic or interfere with the body’s hormones, known as the endocrine system.

How do obesogens promote weight gain?

Obesogens cause weight gain by altering lipid homeostasis to promote adipogenesis and lipid accumulation, and this may occur by multiple mechanisms, including the following: Increasing the number of fat cells (adipocytes) Increasing the size of fat cells (adipocytes), storage of fat per cell, or both.

What are the four types of endocrine disruptors?

These include polychlorinated biphenyls (PCBs), polybrominated biphenyls (PBBs), and dixons. Other examples of endocrine disruptors include bisphenol A (BPA) from plastics, dichlorodiphenyltrichloroethane (DDT) from pesticides, vinclozolin from fungizides, and diethylstilbestrol (DES) from pharmaceutical agents.

What chemicals cause weight gain?

The chemicals that cause weight gain are called obesogens—hormones and pesticides in conventional meat and produce, plastic packaging, additives in processed foods, and even household cleaners.

Can obesity cause endocrine disorders?

Obesity is associated with several endocrine diseases, including common ones such as hypothyroidism and polycystic ovarian syndrome to rare ones such as Cushing’s syndrome, central hypothyroidism and hypothalamic disorders.

What are the most common endocrine disruptors?

The most common endocrine disruptors

  • PCBs and dioxins. Found in: Pesticides.
  • Flame retardants. Found in: Plastics, paint, furniture, electronics, food.
  • Dioxins. Found in: Meat.
  • Phytoestrogens. Found in: Soy & other foods.
  • Pesticides. Found in: Food, water, soil.
  • Perfluorinated chemicals.
  • Phthalates.
  • BPA (bisphenol A)

What are metabolism disruptors?

Metabolism disruptors are endocrine disruptors that increase the susceptibility to metabolic diseases. • Some metabolism disruptors may cause metabolic diseases per se while others act via increasing the sensitivity or set point for disease.

How do obesogens affect metabolism?

Obesogens exert their effects via reprogramming different signaling pathways that have common endpoints in tissues crucial for whole-body metabolism, resulting in increased adiposity and/or altered function of adipose tissue.

Does BPA cause obesity?

Several studies have shown that BPA increased the risk of metabolic disorders and obesity by changing the endocrine-metabolic pathways in adipose tissue [5,20]. BPA increases the number and size of adipocytes by regulating the expression of genes such as FABP4, CD36, and PCSK1 [5].

Do endocrine disruptors cause weight gain?

Recent Findings. Recent findings demonstrate that such endocrine-disrupting chemicals, termed “obesogens”, can promote adipogenesis and cause weight gain.

What is the difference between environmental obesogen and endocrine disrupting chemicals?

An environmental obesogen is defined as a chemical that can alter lipid homeostasis to promote adipogenesis and lipid accumulation whereas an endocrine disrupting chemical (EDC) is defined as a synthetic chemical that can interfere with the endocrine function and cause adverse health effects.

Do endocrine-disrupting chemicals increase the risk of obesity?

The effect of exposure to endocrine-disrupting chemicals on the initiation or exacerbation of obesity, which may significantly alter the perception of the etiology of obesity and impact intervention and prevention efforts, is an important emerging area needing even further research emphasis. Obesity is a growing concern worldwide.

How do endocrine-disrupting chemicals (EDCs) affect body fat?

The obesogenic activity of endocrine-disrupting chemicals (EDCs) results in increased body fat: since EDCs are lipophilic, more EDCs will be stored as the amount of body fat increases.

Do endocrine-disrupting chemicals promote adipogenesis?

Recent findings demonstrate that such endocrine-disrupting chemicals, termed “obesogens”, can promote adipogenesis and cause weight gain.