Can Demerol be given with MAOI?
Meperidine is contraindicated in patients who are receiving monoamine oxidase (MAO) inhibitors or those who have recently received such agents. Therapeutic doses of meperidine have occasionally precipitated unpredictable, severe, and occasionally fatal reactions in patients who have received such agents within 14 days.
What drugs are contraindicated with MAO inhibitors?
MAO inhibitors should be avoided with other antidepressants such as paroxetine fluoxetine, amitriptyline, nortriptyline, bupropion; pain medications like methadone, tramadol, and meperidine; dextromethorphan, St. Johns Wort, cyclobenzaprine, and mirtazapine.
Which opioid should not be used with MAO inhibitors?
Pethidine must never be used in the presence of MAOIs because of the risk of a fatal excitatory interaction. Morphine does not cause this excitatory interaction, and is the drug of choice provided an allowance is made for possible potentiation of the depressive narcotic effect.
Why is opioids contraindicated with MAOI?
Significant drug interactions may occur between MAO inhibitors and opioids and sympathomimetic amines. MAO inhibitors potentiate the depressant activity of opioids. They can produce a hypertensive crisis if combined with specific sympathomimetic amines (see Table 29-7).
What is the difference between MAO inhibitors and SSRIs?
Although SSRIs are the current frontline treatment for depression, MAOIs (monoamine oxidase inhibitors) were the first antidepressants developed. They are typically more potent than SSRIs because they affect more neurotransmitters, and they can cause more side effects.
Which medication is contraindicated when taken with selegiline?
Do not take selegiline if you have used narcotic pain medicines (including meperidine, methadone, tramadol, Demerol®, Dolophine®, Ultram®) or an MAO inhibitor (MAOI) (eg, isocarboxazid, linezolid, phenelzine, tranylcypromine, Marplan®, Nardil®, Parnate®, Zyvox®) within the past 14 days.
Is tramadol a MAO inhibitor?
The highest risk opioid drugs are tramadol, pethidine and dextromethorphan. The highest risk serotonergic drugs are the irreversible monoamine oxidase inhibitor (MAOI) antidepressants, tranylcypromine and phenelzine. The risk and precautions with different combinations are summarised in the Table.
Does tramadol inhibit monoamine uptake?
Tramadol. A number of studies have shown that tramadol in the low micromolar range inhibits serotonin uptake by rat cortical synaptosomes38, 39, 40, 41, 42, 90 and by human SERT46, 47, 48 (Table 1).
Does tramadol interact with MAOIs?
Do NOT take tramadol with a monoamine oxidase inhibitor (MAOI) (e.g., antidepressants phenelzine, tranylcypromine, or moclobemide; Parkinson’s disease medications selegiline or rasagiline) or within 14 days of stopping a MAOI.
Can you take tramadol with Trintellix?
Combining these medications can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or …
What is the main ingredient in Demerol?
The DEMEROL Oral Solution is a pleasant-tasting, nonalcoholic, banana-flavored solution containing 50 mg of meperidine hydrochloride, per 5 mL (10 mg/mL). The Inactive Ingredients in DEMEROL Tablets include: Calcium Sulfate, Dibasic Calcium Phosphate, Starch, Stearic Acid, and Talc.